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Cicaloni Vittoria

Tutor: Dott.ssa Cristina TINTI (TLS)

Tutor: Prof.ssa Annalisa SANTUCCI (UniSi)

I was a PhD student in Biochemistry and Molecular Biology (XXXII cycle) at the Biotechnology, Chemistry and Pharmacy Dept. of University of Siena and at Toscana Life Sciences Foundation (TLS). My PhD project is focused on the application of a Precision Medicine approach to rare diseases, development of integrated and interactive databases, algorithms for patient stratification and proteomics data analysis. I am the author of numerous papers on international scientific journals and I was speaker at several meetings such as the regional section meeting of the Bioinformatics Italian Society (BITS) and Re(ACT) International Congress. Thanks to BiBim 2.0 PhD program I have consolidated a multidisciplinary scientific background ranging over different competences and I have worked in continuous collaboration between academic and industrial environment. 

Her publications during the Phd program:

Spiga O, Cicaloni V, Fiorini C, Trezza A, Visibelli A, Millucci L, Bernardini G, Bernini
A, Marzocchi B, Braconi D, Prischi F, Santucci A. Machine learning application for
development of a data-driven predictive model able to investigate quality of life scores
in a rare disease. Orphanet J Rare Dis 15, 46 (2020).
 Cicaloni V, Spiga O, Dimitri GM, Maiocchi R, Millucci L, Giustarini D, Bernardini G,
Bernini A, Marzocchi B, Braconi D, Santucci A. Interactive alkaptonuria database:
investigating clinical data to improve patient care in a rare disease. FASEB J. (2019)
33(11):12696-12703.
 Cicaloni V, Trezza A, Pettini F, Spiga O. Applications of in Silico Methods for Design
and Development of Drugs Targeting Protein-Protein Interactions. Curr Top Med
Chem. (2019) 19(7):534-554.
 Ascher DB, Spiga O, Sekelska M, Pires DEV, Bernini A, Tiezzi M, Kralovicova
J, Borovska I, Soltysova A, Olsson B, Galderisi S, Cicaloni V, Ranganath L, Santucci
A, Zatkova A. Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis
and genotype–phenotype correlations in the largest cohort of patients with AKU. Eur J
Hum Genet. (2019) 27(6):888-902. 
 Braconi D, Cicaloni V, Spiga O, Santucci A. Chapter 1 – An Introduction to
Personalized Nutrition. Trends in Personalized Nutrition (2019) 3-32.
 Spiga O, Gardini S, Rossi N, Cicaloni V, Pettini F, Niccolai N, Santucci A. Structural
investigation of Rett-inducing MeCP2 mutations. Genes & Diseases. (2018) 6(1):31-
34.
 Cicaloni V, Spiga O, Zatkova A, Millucci L, Bernardini G, Bernini A, Marzocchi B,
Bianchini M, Zugarini A, Rossi A, Zazzeri M, Trezza A, Frediani B, Ranganath L,
Braconi D, Santucci A. A new integrated and interactive tool applicable to inborn errors
of metabolism: Application to alkaptonuria. Computers in Biology and Medicine (2018)
103:1–7.
 Trezza A, Cicaloni V, Porciatti P, Langella A, Fusi F, Saponara S, Spiga O. From in
silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-
sensitive inward rectifier potassium channel. PeerJ (2018) 6:e4680.
 Cicaloni V, Spiga O, Bernini A, Zatkova A, Santucci A. ApreciseKUre: an approach

of Precision Medicine in a Rare Disease. BMC Medical Informatics and Decision
Making (2017) 17:42.
 Cicaloni V, Zugarini A, Rossi A, Zazzeri M, Santucci A, Bernini A, Spiga O. Towards
an integrated interactive database for the search of stratification biomarkers in
Alkaptonuria. PeerJ Preprints (2016) 4:e2174v1.